Articles

Algorithmic assessment of cellular senescence in experimental and clinical specimens

Nature, Nature Protocols, Published 28 April 2021

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Down-Regulation of the Proteoglycan Decorin Fills in the Tumor-Promoting Phenotype of Ionizing Radiation-Induced Senescent Human Breast Stromal Fibroblasts

PMC 2021 Apr; 13(8): 1987

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Hepatic Senescence Accompanies the Development of NAFLD in Non-Aged Mice Independently of Obesity

PMC 2021 Apr; 22(7): 3446.

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Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

Mol Cell 2021 Mar 27;S1097-2765(21)00213-6. doi: 10.1016/j.molcel.2021.03.018.

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Implication of Dietary Iron-Chelating Bioactive Compounds in Molecular Mechanisms of Oxidative Stress-Induced Cell Ageing

2021 Mar; 10(3): 491. Published online 2021 Mar 21. doi: 10.3390/antiox10030491

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Intra-Articular Injection of (−)-Epigallocatechin 3-Gallate (EGCG) Ameliorates Cartilage Degeneration in Guinea Pigs with Spontaneous Osteoarthritis



2021 Feb; 10(2): 178. Published online 2021 Jan 26. doi: 10.3390/antiox10020178


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A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer

In Vivo. Nov-Dec 2020;34(6):3187-3193. doi: 10.21873/invivo.12154.

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The bright and dark side of skin senescence. Could skin rejuvenation anti-senescence interventions become a "bright" new strategy for the prevention of age-related skin pathologies?

Elsevier Volume 193, January 2021, 111409

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Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells

2020 Sep; 21(17): 6084. Published online 2020 Aug 24. doi: 10.3390/ijms21176084

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Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation

2020; 11: 2711. Published online 2020 Jun 1. doi: 10.1038/s41467-020-16475-3


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Conditioning attenuates kidney and heart injury in rats following transient suprarenal occlusion of the abdominal aorta

2020; 10: 5040. Published online 2020 Mar 19. doi: 10.1038/s41598-020-61268-9

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ZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts

2020 May; 11(5): 359. Published online 2020 May 12. doi: 10.1038/s41419-020-2552-7

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Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation

PMC 2020 Sep 15; 147(6): 1528–1534.

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Immunohistochemical detection of senescence markers in human sarcomas

  • PMID: 31899047
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  • DOI: 10.1016/j.prp.2019.152800


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Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

2020; 11: 42. Published online 2020 Jan 2. doi: 10.1038/s41467-019-13894-9


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Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression

MDPI Cancers (Basel). 2020;12(7):1825. Published 2020 Jul 7. doi:10.3390/cancers12071825


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Cellular Senescence: Defining a Path Forward

Cell Oct 31 2019;179(4):813-827. 


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Immunohisto(cyto)chemistry: an old time classic tool driving modern oncological therapies

Histol Histopathol. 2019 Apr;34(4):335-352. 


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Robust, universal biomarker assay to detect senescent cells in biological specimens

Aging Cell. 2017 Feb;16(1):192-197. 


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Detecting senescence: a new method for an old pigment

Aging Cell (2017)16, pp432–434. 


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A novel Sudan Black B-based analogue revives lipofuscin as a biomarker for in vivo senescence

Virchows Archiv December 2018, Volume 473, Issue 6, pp 781–783 doi: 10.1007/s00428-018-2452-8


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Tracking senescent cells: A new biomarker assay opens new avenues in senescence research

Mech Ageing Dev. 2017 Mar;162:106-107. doi: 10.1016/j.mad.2017.01.009. Epub 2017 Feb 1. 


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A prototypical non-malignant epithelial mode; to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

BMC Genomics. 2018 Jan 10;19(1):37 


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Senescence and senotherapeutics: a new field in cancer therapy


Pharmacol Ther. 2019 Jan;193:31-49. 


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Ageing, Cellular Senescence and Neurodegenerative Disease


Int J Mol Sci. 2018 Sep 27;19(10) 


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Sasaki M, Sato Y, Nakanuma Y. An impaired biliary bicarbonate umbrella may be involved in dysregulated autophagy in primary biliary cholangitis

Lab Invest. 2018 Jun;98(6):745-754. 


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Integrating the DNA damage and protein stress responses during cancer development and treatment

J Pathol. 2018 Sep;246(1):12-40. doi: 10.1002/path.5097 


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The innate immune sensor Toll like receptor 2 controls the senescence-associated secretory phenotype

Sci. Adv. 2019; 5 : eaaw0254. 


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In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

Mech Ageing Dev. 2019 Jan;177:88-90. 


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An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro‐inflammatory program


Aging Cell. 2019;e12933. 


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Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells

Nucleic Acids Research, 2019, Vol. 47, No. 6 


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